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RAB11-Mediated Trafficking and Human Cancers: An Updated Review

Elsi Ferro1,2, Carla Bosia1,2, Carlo C Campa1,2

  • 1Department of Applied Science and Technology, Politecnico di Torino, 24 Corso Duca degli Abruzzi, 10129 Turin, Italy.

Biology
|January 7, 2021
PubMed

Insights

The small GTPase RAB11 family regulates vesicular trafficking, impacting cancer cell survival and metastasis. Understanding RAB11 pathways is crucial for comprehending cancer progression and developing targeted therapies.

Area of Science:

  • Cell Biology
  • Molecular Oncology
  • Cancer Research

Background:

  • Cellular processes are often subverted by diseases like cancer.
  • The small GTPase RAB11 family, a key regulator of vesicular trafficking, is frequently altered in human cancers.

Purpose of the Study:

  • To review the biological mechanisms of cargo recognition and sorting via RAB11-dependent pathways.
  • To elucidate the role of RAB11 alterations in human cancer progression.

Main Methods:

  • Literature review focusing on RAB11-dependent vesicular trafficking.
  • Analysis of RAB11 isoform functions in membrane organization, autophagy, and cell protrusion.

Main Results:

  • RAB11 isoforms are critical for connecting cargo transport to the plasma membrane, autophagosome assembly, and cellular protrusion formation.
  • Alterations in RAB11 pathways significantly influence cancer cell survival, metastasis, and the accumulation of toxic cellular materials.

Conclusions:

  • RAB11-dependent pathways are fundamental to cellular physiology and are implicated in cancer development.
  • A comprehensive understanding of these pathways is essential for targeting RAB11 in cancer therapy.
Keywords:
RAB11RAB25cancerendosomesorting

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