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Nuclear Ubiquitin-Proteasome Pathways in Proteostasis Maintenance
Dina Franić1, Klara Zubčić1, Mirta Boban1
1Croatian Institute for Brain Research, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Biomolecules
|January 7, 2021
Summary
Maintaining protein homeostasis (proteostasis) is vital for cell function. This review details nuclear protein quality control pathways, including INMAD and San1, that prevent harmful protein aggregation and neurodegenerative diseases.
Area of Science:
- Cell Biology
- Molecular Biology
- Neuroscience
Background:
- Protein homeostasis (proteostasis) is essential for cellular function, involving protein structure, localization, and concentration.
- Imbalances in proteostasis are linked to neurodegenerative diseases like Alzheimer's and Parkinson's.
- Protein quality control (PQC) pathways, primarily the ubiquitin-proteasome system, eliminate damaged proteins.
Purpose of the Study:
- To review nuclear ubiquitin-proteasome pathways crucial for proteostasis.
- To focus on inner nuclear membrane-associated degradation (INMAD) and San1-mediated PQC in yeast.
Main Methods:
- Literature review of nuclear PQC pathways.
- Focus on yeast models for INMAD and San1 mechanisms.
Main Results:
- The nucleus is an important PQC compartment for degrading both nuclear and cytoplasmic proteins.
- INMAD and San1-mediated degradation are key nuclear PQC pathways in yeast.
Conclusions:
- Nuclear PQC pathways play a critical role in maintaining cellular proteostasis.
- Understanding these pathways, particularly INMAD and San1, offers insights into preventing protein misfolding diseases.
Keywords:
inner nuclear membranenucleusproteasomeprotein misfoldingprotein quality controlproteostasisubiquitinyeastMore Related Videos
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