Myeloma cast nephropathy with diffuse amyloid casts without systemic amyloidosis: two cases report
Zi-Hao Yong1,2,3,4,5,6,7, Xiao-Juan Yu8,9,10,11,12, Zi-Shan Lin1,2,3,4,5
1Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, People's Republic of China.
BMC Nephrology
|January 7, 2021
Summary
This study reports two rare cases of myeloma cast nephropathy (MCN) with diffuse amyloid casts, highlighting the potential role of tubular epithelial cells in this severe kidney complication of multiple myeloma (MM).
Area of Science:
- Nephrology
- Hematology
- Pathology
Background:
- Multiple myeloma (MM) is a plasma cell malignancy causing kidney damage through monoclonal immunoglobulin deposition.
- Myeloma cast nephropathy (MCN) is a common and severe renal complication of MM.
- Amyloid casts, formed by free light chains, are a rare manifestation of MCN.
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