Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alternative RNA Splicing02:18

Alternative RNA Splicing

23.9K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
23.9K
Alternative RNA Splicing02:18

Alternative RNA Splicing

4.4K
4.4K
RNA Splicing01:32

RNA Splicing

59.1K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
59.1K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.4K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.4K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.1K
3.1K
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

7.7K
In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Postinfectious polyneuritis cranialis: A case report.

The Journal of international medical research·2026
Same author

CD163 protects against pulmonary injury and inflammation induced by acute O<sub>3</sub> exposure.

bioRxiv : the preprint server for biology·2026
Same author

TELO2-interacting protein 1 (TTI1), a novel Wnt/β-catenin target gene, decreases chemo-sensitivity in colorectal cancer by modulating DNA damage responses.

Molecular biomedicine·2026
Same author

Aspirin protects trophoblast function against hypoxia-induced oxidative stress through activation of NRF2 signaling in preeclampsia.

Reproductive biology·2026
Same author

Targeting CDK4 with repurposing perphenazine inhibited the growth of gastric cancer AGS and HGC27 cells by arresting cell cycle.

Biochemical pharmacology·2026
Same author

scRNA-seq analysis shows neutrophil extracellular traps as drivers of obstruction-induced intestinal damage in rats.

Communications biology·2026
Same journal

Extracellular vesicle-mediated GALNT1/RPRD1A glycosylation axis drives immune escape and peritoneal metastasis in gastric cancer.

Journal of experimental & clinical cancer research : CR·2026
Same journal

NHE7-Driven endoplasmic reticulum stress signaling transmission promotes malignant progression of endometrial cancer via c-Fos/PRSS1/ERP27 axis.

Journal of experimental & clinical cancer research : CR·2026
Same journal

Correction: Nanovaccines with ferroptosis, necroptosis and STING-activation for synergistic immunotherapy.

Journal of experimental & clinical cancer research : CR·2026
Same journal

Adipocyte-rich microenvironment promotes TNBC progression through SIRT6-associated ACSL5 dysregulation and lipid storage-associated phenotypes.

Journal of experimental & clinical cancer research : CR·2026
Same journal

Correction: Copy number amplification-induced overexpression of lncRNA LOC101927668 facilitates colorectal cancer progression by recruiting hnRNPD to disrupt RBM47/p53/p21 signaling.

Journal of experimental & clinical cancer research : CR·2026
Same journal

Decoding glioblastoma evolution and heterogeneity through mechanistic modeling: implications for clinical translation.

Journal of experimental & clinical cancer research : CR·2026
See all related articles

Related Experiment Video

Updated: Nov 22, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

9.2K

Noncoding RNAs regulate alternative splicing in Cancer.

Yunze Liu1,2, Xin Liu3, Changwei Lin4

  • 1Department of General Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.

Journal of Experimental & Clinical Cancer Research : CR
|January 7, 2021
PubMed
Summary
This summary is machine-generated.

Alternative splicing (AS) defects drive cancer progression. Noncoding RNAs (ncRNAs) regulate AS in cancer, influencing invasion, metastasis, and drug resistance, offering potential as biomarkers and therapeutic targets.

Keywords:
Alternative splicingCancerNoncoding RNAcircRNAlncRNAmiRNAsnRNA

More Related Videos

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

13.2K
Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

5.2K

Related Experiment Videos

Last Updated: Nov 22, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

9.2K
Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

13.2K
Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

5.2K

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Genetics

Background:

  • Alternative splicing (AS) generates protein diversity but its defects are implicated in cancer.
  • Noncoding RNAs (ncRNAs), including miRNAs, lncRNAs, and circRNAs, are key regulators in biological processes.
  • Dysregulation of AS is a hallmark of cancer, contributing to tumorigenesis and progression.

Purpose of the Study:

  • To review mechanisms of ncRNA-mediated regulation of AS in cancer.
  • To explore the role of ncRNA-regulated AS in cancer hallmarks like invasion and drug resistance.
  • To discuss the clinical potential of ncRNA-AS interactions as cancer biomarkers and therapeutic targets.

Main Methods:

  • Literature review of studies on ncRNAs, AS, and cancer.
  • Analysis of molecular mechanisms by which ncRNAs influence AS.
  • Synthesis of evidence linking ncRNA-AS pathways to cancer progression and clinical outcomes.

Main Results:

  • NcRNAs modulate AS by targeting regulatory factors and pre-mRNA.
  • Altered AS isoforms driven by ncRNAs contribute to cancer hallmarks.
  • Specific ncRNA-AS interactions are associated with cancer invasion, metastasis, and therapy resistance.

Conclusions:

  • NcRNAs play a critical role in regulating AS in the context of cancer.
  • Targeting ncRNA-AS pathways presents promising avenues for cancer diagnostics and therapeutics.
  • Further research is needed to fully elucidate and translate these findings into clinical practice.