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RMRP, RMST, FTX and IPW: novel potential long non-coding RNAs in medullary thyroid cancer

Berta Luzón-Toro1,2, Leticia Villalba-Benito1,2, Raquel María Fernández1,2

  • 1Department of Maternofetal Medicine, Genetics and Reproduction, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Rocío/CSIC, University of Seville, Seville, Spain.

Orphanet Journal of Rare Diseases
|January 7, 2021
PubMed

Insights

This study validates novel long non-coding RNAs (lncRNAs) in medullary thyroid cancer (MTC). Preliminary results suggest RMST, FTX, IPW, and RMRP play a role in MTC pathogenesis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Medullary thyroid cancer (MTC) is a rare neuroendocrine tumor with sporadic (sMTC) and inherited (MEN2) forms.
  • Multiple Endocrine Neoplasia type 2 (MEN2) is linked to RET proto-oncogene mutations.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their role in cancer, but their involvement in MEN2 is unexplored.

Discussion:

  • This study validates previously identified lncRNAs (RMST, FTX, IPW, RMRP) in a larger cohort of MTC patients.
  • RT-qPCR analysis was performed on formalin-fixed paraffin-embedded tissues from MEN2 and sMTC patients.
  • The expression levels of RMST, FTX, and IPW were found to be up-regulated, while RMRP was down-regulated.

Key Insights:

  • RMST, FTX, and IPW show potential as up-regulated biomarkers in MTC pathogenesis.
  • RMRP demonstrates potential as a down-regulated biomarker in MTC pathogenesis.
  • These findings support the involvement of specific lncRNAs in the development of MTC.

Outlook:

  • Further research is needed to elucidate the precise mechanisms by which these lncRNAs influence MTC.
  • Validation in larger, diverse patient cohorts and functional studies are crucial.
  • These lncRNAs may represent novel therapeutic targets or diagnostic markers for MTC.
Keywords:
FTXIPWMEN2MTCRMRPRMSTlncRNA

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