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Related Experiment Videos

In-111-labeled liposomes: dosimetry and tumor depiction.

A F Turner1, C A Presant, R T Proffitt

  • 1Department of Radiology, San Gabriel Medical Center, CA 91776.

Radiology
|March 1, 1988
PubMed
Summary

Indium-111 labeled liposomes show uptake in liver and spleen, with 92% of patients revealing tumor sites. These In-111 liposomes may help detect suspected or unsuspected tumors.

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Area of Science:

  • Nuclear medicine
  • Oncology
  • Nanotechnology

Background:

  • Liposomes are neutral phospholipid vesicles used for drug delivery.
  • Indium-111 (In-111) is a radioisotope used in diagnostic imaging.

Purpose of the Study:

  • To evaluate the biodistribution and dosimetry of In-111 labeled liposomes in cancer patients.
  • To assess the potential of In-111 liposomes for tumor imaging.

Main Methods:

  • Neutral phospholipid vesicles (liposomes) were labeled with In-111.
  • 24 cancer patients received In-111 liposomes intravenously.
  • Scintigraphic scans were performed at 24 and 48 hours post-injection.

Main Results:

  • Liposomes had a median diameter of 77 nm.

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  • Homogeneous uptake was observed in the liver and spleen with low radiation doses.
  • Tumor sites were visualized in 22 out of 24 patients (92%).

    • Conclusions:

    • In-111 labeled liposomes demonstrate favorable biodistribution and low dosimetry in normal organs.
    • This imaging agent shows promise for detecting known and unknown tumor locations in cancer patients.