Related Experiment Video
Updated: Nov 22, 2025

Potentiodynamic Corrosion Testing
Published on: September 4, 2016
[Metal Debris with Cobalt Intoxication and Heart Damage as a THA Complication]
J Hach1, M KubÁnek, D PelclovÁ
1Ortopedicko-traumatologické oddělení nemocnice Mělník.
Insights
Chronic metal poisoning from failed total hip replacement (THA) can cause severe heart damage. This study highlights two cases of heart failure requiring transplantation due to metal toxicity from artificial hip joints.
Area of Science:
- Orthopaedic Surgery
- Toxicology
- Cardiology
Background:
- Total hip replacement (THA) is a common orthopaedic procedure.
- Complications from wear of prosthetic components have been documented.
- Emerging evidence links systemic metal wear to organ damage.
Observation:
- This case report details two patients who developed severe heart damage.
- The cardiac complications progressed to heart failure.
- Both patients required heart transplantation.
Findings:
- The observed heart damage and failure were directly attributed to chronic metal poisoning.
- The metal poisoning originated from wear debris of the failed total hip arthroplasty components.
- This highlights a severe, previously underreported complication of THA.
Implications:
- Clinicians should consider metal poisoning from THA in patients with unexplained cardiac issues.
- Further research is needed to understand the mechanisms of metal-induced cardiotoxicity.
- This case report emphasizes the importance of long-term monitoring for complications associated with orthopaedic implants.
Abstract:
Total hip replacement is currently a standard orthopaedic procedure. A number of complications caused by wear of the articulating parts of the endoprosthesis were described in the past. In recent years, there have been reports of systemic manifestations of metal components wear, leading to the development of chronic metal poisoning and organ damage. Our case report documents two cases of heart damage, resulting in heart failure with the need for heart transplantation, caused by metal poisoning originating from a failed THA.
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