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Tornado-inspired acoustic vortex tweezer for trapping and manipulating microbubbles.

Wei-Chen Lo¹, Ching-Hsiang Fan^2,3, Yi-Ju Ho¹

¹Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 30013 Taiwan.

Proceedings of the National Academy of Sciences of the United States of America

|January 7, 2021

Summary

Acoustic vortex tweezers (AVT) noninvasively trap microbubbles for targeted drug delivery. This novel method enhances drug concentration and retention in specific areas, improving therapeutic efficacy with minimal dosage.

Keywords:

acoustic tweezers acoustic vortex microbubbles trapping ultrasound

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Area of Science:

Biomedical Engineering
Acoustic Manipulation
Drug Delivery Systems

Background:

Systemic drug delivery faces challenges with blood flow velocity, limiting therapeutic agent retention at target sites.
Current methods for intravascular drug delivery often result in significant drug leakage and poor localized concentration.
Lipid-shelled gaseous microbubbles (MBs) are versatile for medical applications, including contrast imaging and drug/gene delivery.

Purpose of the Study:

To introduce a novel acoustic vortex tweezer (AVT) technique for noninvasive intravascular trapping and manipulation of microbubbles (MBs).
To address the limitations of systemic drug delivery by enhancing localized drug concentration and retention.
To demonstrate the efficacy of AVT in both static and dynamic blood flow conditions.

Main Methods:

Development and application of a tornado-inspired acoustic vortex tweezer (AVT) system.
Utilizing lipid-shelled gaseous microbubbles (MBs) as carriers for therapeutic agents.
Testing AVT's ability to trap and concentrate MBs in static and flow conditions, including in mouse capillaries.

Main Results:

AVT successfully trapped microbubbles (MBs) and increased their local concentration in both static and flow conditions.
Microbubble signals within mouse capillaries showed a local improvement of 1.7-fold.
The location of trapped MBs was successfully manipulated during AVT initiation.

Conclusions:

Acoustic vortex tweezer (AVT) offers a compact, user-friendly, and biocompatible method for intravascular microbubble manipulation.
AVT enables noninvasive trapping and concentration of therapeutic agents, overcoming challenges associated with high blood flow velocity.
This technique holds promise for highly efficient systemic drug administration at extremely low doses.