Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

RNA-seq03:21

RNA-seq

11.1K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
11.1K
Genomics02:02

Genomics

38.8K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
38.8K
Proteomics01:33

Proteomics

8.9K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
8.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An environmental-friendly process for dissociating toxic substances and recovering valuable components from spent carbon cathode.

Journal of hazardous materials·2020
Same author

Clinical observation on therapeutic effect of filiform fire needle for vitiligo: A retrospective study.

Dermatologic therapy·2020
Same author

Decreased expression of prohibitin 1 mediates high<b>-</b>mobility group protein 1<b>-</b>induced pulmonary artery endothelial cell injury.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2020
Same author

Reliability and validity of the Caregiver Reported Early Development Instruments (CREDI) in impoverished regions of China.

BMC pediatrics·2020
Same author

Abnormalities of ILC1 in children with hand, foot and mouth disease during enterovirus 71 infection.

Virology·2020
Same author

Utility of the gastric window in computed tomography for differentiation of early gastric cancer (T1 stage) from muscularis involvement (T2 stage).

Abdominal radiology (New York)·2020
Same journal

ClairS: a deep-learning method for long-read tumor-normal pair somatic small variant calling.

Nature methods·2026
Same journal

RNAbpFlow: base pair-augmented SE(3) flow matching for conditional RNA 3D structure generation.

Nature methods·2026
Same journal

Spatio-DARLIN enables robust and efficient in situ lineage tracing in mice at single-cell resolution.

Nature methods·2026
Same journal

EasyGrid: a versatile platform for automated cryo-EM sample preparation and quality control.

Nature methods·2026
Same journal

Cloud-based microscope enables live neuroimaging for 24 h and beyond with worldwide access.

Nature methods·2026
Same journal

Deep molecular profiling in three dimensions.

Nature methods·2026
See all related articles

Related Experiment Video

Updated: Nov 22, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.2K

Multiomics sequencing goes spatial.

Lei Tang1

  • 1Nature Methods, . lei.tang@nature.com.

Nature Methods
|January 7, 2021
PubMed
Summary
This summary is machine-generated.

Microfluidic channels deliver spatial barcodes to tissues for simultaneous gene expression and protein analysis. This enables precise mapping of molecular data within biological samples.

More Related Videos

Mining Spatial Transcriptomics Datasets using DeepSpaceDB
10:16

Mining Spatial Transcriptomics Datasets using DeepSpaceDB

Published on: September 5, 2025

410
Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
06:24

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

3.9K

Related Experiment Videos

Last Updated: Nov 22, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.2K
Mining Spatial Transcriptomics Datasets using DeepSpaceDB
10:16

Mining Spatial Transcriptomics Datasets using DeepSpaceDB

Published on: September 5, 2025

410
Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
06:24

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

3.9K

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Genomics

Background:

  • Spatial information is crucial for understanding tissue function and disease.
  • Current methods for spatial profiling are often limited in scope or resolution.

Purpose of the Study:

  • To introduce a microfluidic system for delivering spatial barcodes to tissues.
  • To enable co-profiling of gene expression and proteins in a spatially resolved manner.

Main Methods:

  • Utilizing microfluidic channels to deliver barcoded reagents.
  • Applying techniques for simultaneous gene expression and protein detection.

Main Results:

  • Successful delivery of spatial barcodes to tissue samples.
  • Demonstration of co-profiling gene expression and proteins with spatial resolution.

Conclusions:

  • Microfluidic-based spatial barcoding is a viable approach for multi-omic tissue analysis.
  • This technology enhances the ability to study complex biological systems at a spatial level.