Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mind the gap: making headway in functional visual loss.

Eye (London, England)·2026
Same author

Tea tree oil action on human corneal epithelial cells biological activity.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same author

Recruiting children and young people with vision impairment for clinical research - experience from the SeeMyLife study.

BMC medical research methodology·2026
Same author

Vascular Changes in the Macula and Peripapillary Regions Using Optical Coherence Tomography Angiography in Migraine with Aura and Migraine Without Aura.

Journal of clinical medicine·2026
Same author

Optical coherence tomography measurement of retinal layers above the peripapillary hyperreflective ovoid mass-like structure in true papilloedema and pseudo-papilloedema.

Eye (London, England)·2026
Same author

Clinical and Demographic Predictors of Optic Neuritis Subtype.

Neuro-ophthalmology (Aeolus Press)·2026

Related Experiment Video

Updated: Nov 22, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

3.9K

Multirater Validation of Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS).

Axel Petzold1,2, Valerie Biousse3, Lulu Bursztyn4

  • 1Moorfields Eye Hospital NHS Foundation Trust and the National Hospital for Neurology and Neurosurgery, Queen Square, Institute of Neurology, University College London, London, UK.

Neuro-Ophthalmology (Aeolus Press)
|January 7, 2021
PubMed
Summary

The 2018 definition for peripapillary hyperreflective ovoid mass-like structures (PHOMS) showed poor reliability. A refined definition, developed through expert consensus, significantly improved detection agreement for these new optical coherence tomography (OCT) findings.

Keywords:
OCTODDPHOMS

More Related Videos

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.6K
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
09:31

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

Published on: March 30, 2015

9.1K

Related Experiment Videos

Last Updated: Nov 22, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

3.9K
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.6K
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
09:31

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

Published on: March 30, 2015

9.1K

Area of Science:

  • Ophthalmology
  • Medical Imaging

Background:

  • Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are a novel finding on optical coherence tomography (OCT).
  • Previous recommendations in 2018 aimed to differentiate PHOMS from optic disc drusen (ODD).
  • The diagnostic accuracy and inter-rater reliability of the 2018 PHOMS definition remain unassessed.

Purpose of the Study:

  • To evaluate the reliability of the 2018 PHOMS definition.
  • To develop a refined and consistent definition for PHOMS using a Delphi consensus process.
  • To improve the diagnostic accuracy and inter-rater agreement for PHOMS detection.

Main Methods:

  • A multi-rater study assessed the reliability of the 2018 PHOMS definition.
  • A Delphi consensus process involving expert raters was conducted.
  • Teaching slides and 50 OCT scans were used to refine the definition and train raters.

Main Results:

  • The 2018 PHOMS definition yielded a poor multi-rater kappa of 0.356.
  • The refined definition, developed through consensus and training, achieved a good inter-rater agreement (kappa 0.701).
  • Fifty explanatory slides and 50 OCT scans facilitated high agreement among 21 expert raters.

Conclusions:

  • The initial 2018 definition for PHOMS lacks sufficient reliability for clinical use.
  • A refined definition, established via expert consensus and educational materials, significantly enhances diagnostic agreement.
  • Adoption of the refined PHOMS definition is recommended for consistent identification in OCT imaging.