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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Updated: Nov 22, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
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Circular RNA circGSE1 Promotes Cervical Cancer Progression Through miR-138-5p/Vimentin.

Suzhen Fan1, Shujun Zhao1, Xiang Gao1

  • 1Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, People's Republic of China.

Oncotargets and Therapy
|January 7, 2021
PubMed
Summary
This summary is machine-generated.

Circular RNA circGSE1 is elevated in cervical cancer, promoting tumor progression and metastasis by sponging miR-138-5p and upregulating Vimentin. High circGSE1 levels indicate a poorer prognosis.

Keywords:
Vimentincervical cancercircGSE1miR-138-5pmigration and metastasis

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are increasingly recognized for their roles in tumor progression.
  • The specific functions of circRNAs in cervical cancer remain largely uncharacterized.

Purpose of the Study:

  • To investigate the role and mechanism of circGSE1 in cervical cancer.
  • To explore circGSE1 as a potential diagnostic biomarker for cervical cancer progression.

Main Methods:

  • Quantitative real-time PCR (qRT-PCR) to measure circGSE1 levels.
  • In vitro assays (wound healing, Transwell) to assess cell migration and invasion.
  • Molecular assays (pull-down, luciferase reporter, RIP) to elucidate the circGSE1/miR-138-5p/Vimentin interaction.

Main Results:

  • CircGSE1 expression is significantly upregulated in cervical cancer tissues and correlates with advanced tumor features and poor survival.
  • CircGSE1 promotes cervical cancer cell migration and invasion.
  • CircGSE1 acts as a molecular sponge for miR-138-5p, leading to increased Vimentin expression and enhanced cell motility.

Conclusions:

  • CircGSE1 facilitates cervical cancer progression and metastasis.
  • CircGSE1 shows potential as a novel diagnostic biomarker for cervical cancer disease progression.