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Interactive Effect of IGF2BP2 rs4402960 Variant, Smoking and Type 2 Diabetes
Oswald Ndi Nfor1, Nokuphila Balindile Ndzinisa1, Meng-Hsiun Tsai2
1Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City 40201, Taiwan.
Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
|January 7, 2021
Summary
Smoking and the IGF2BP2 gene rs4402960 polymorphism significantly increase type 2 diabetes risk in Taiwanese adults. The risk is particularly high for current smokers with the GG genotype.
Area of Science:
- Genetics and Epidemiology
- Metabolic Disease Research
Background:
- Type 2 diabetes (T2D) is influenced by both genetic and environmental factors.
- Understanding genetic modifiers of T2D, especially in smokers, is crucial for targeted prevention.
Purpose of the Study:
- To investigate the interaction between the IGF2BP2 gene rs4402960 polymorphism and smoking on T2D risk in Taiwanese adults.
Main Methods:
- Utilized genetic data from 22,039 participants (aged 30-70) in the Taiwan Biobank (2008-2018).
- Employed t-tests, Chi-square tests, and multiple logistic regression for data analysis.
Main Results:
- The rs4402960 TT genotype showed a higher odds ratio (OR) for T2D (1.545) compared to GG.
- Current smokers had a significantly higher T2D risk (OR=1.266).
- A significant interaction (p=0.0497) was found between the IGF2BP2 variant and smoking, with the highest risk in current smokers with the GG genotype (OR=1.663).
Conclusions:
- The study highlights a stronger T2D risk associated with current smoking in individuals with the rs4402960 GG genotype in Taiwan.
- This finding underscores the importance of considering gene-environment interactions in T2D risk assessment.
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