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Risk Factors and Psychological Analysis of Chronic Immune Thrombocytopenia in Children

Ying Sun1, Sili Long1, Wenjun Liu1

  • 1Department of Pediatrics, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China.

International Journal of General Medicine
|January 7, 2021
PubMed

Insights

Risk factors like age of onset and lymphocyte count predict chronic immune thrombocytopenia (ITP) in children. Children with chronic ITP also exhibit psychological differences, particularly in extraversion.

Area of Science:

  • Pediatric Hematology
  • Immunology
  • Child Psychology

Background:

  • Immune thrombocytopenia (ITP) is an autoimmune disorder affecting platelet counts.
  • Chronic ITP (CITP) in children presents unique challenges in management and long-term outcomes.
  • Understanding risk factors and psychological impact is crucial for comprehensive care.

Purpose of the Study:

  • To identify risk factors associated with the chronicity of ITP in pediatric patients.
  • To investigate psychological changes and personality traits in children diagnosed with CITP.
  • To establish predictors for the development of chronic ITP in children.

Main Methods:

  • Retrospective analysis of 234 children with ITP treated between 2016-2018.
  • Clinical and laboratory data were collected to assess ITP chronicity predictors.
  • Eysenck Personality Questionnaire-Children's Version used for psychological assessment.

Main Results:

  • Age of onset, initial lymphocyte count, and diagnosis course were significant predictors of chronic ITP.
  • Absolute lymphocyte count (ALC) emerged as an independent predictor for chronic ITP.
  • Children with CITP showed significant differences in extraversion compared to healthy and newly diagnosed children.

Conclusions:

  • Early indicators like age, initial lymphocyte levels, and diagnosis duration help predict chronic ITP in children.
  • Absolute lymphocyte count is a key independent factor in predicting chronic ITP.
  • Psychological adjustments, especially regarding extraversion, are noted in children with chronic ITP.
Abstract

Keywords:
childrenchronic immune thrombocytopeniapsychologyrisk factors

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