MINDflex Training for Cognitive Flexibility in Chronic Pain: A Randomized, Controlled Cross-Over Trial

Area of Science:

• Neuroscience
• Psychology

Background:

• Executive functioning impairments, particularly cognitive inflexibility, are common in chronic pain.
• Computerized cognitive training (CCT) offers a potential avenue for intervention.

Purpose of the Study:

• To pilot a CCT program based on Relational Frame Theory to enhance cognitive flexibility in chronic pain patients.
• To assess the feasibility and efficacy of the MINDFLEX CCT program.

Main Methods:

• A randomized, cross-over trial involving 73 chronic pain patients at baseline.
• Cognitive flexibility and executive functioning were assessed over 5 months.
• A 40% dropout rate was observed by the final assessment point.

Main Results:

• A substantial learning effect was observed from the MINDFLEX training.
• Significant time-dependent improvements in cognitive flexibility were noted.
• These improvements could not be definitively attributed to the active training component.

Conclusions:

• The study indicates a learning effect and improvements in cognitive flexibility outcomes.
• A larger trial with enhanced training feasibility is recommended for future research.
• Further investigation is needed to establish the direct impact of CCT on chronic pain executive functioning.