Porcine skin damage threshold from mid-infrared optical parametric oscillator radiation at 3.743 µm

There is increasing use of mid-infrared optical parametric oscillator radiation operating in the wavelength range of 3-5 µm. To expand existing damage data for skin exposure to lasers in this wavelength region, the in-vivo damage threshold at the wavelength of 3.743 µm was determined in a Guizhou miniature pig model for an exposure duration of 1.0 s. The irradiance of the laser spot was nearly Gaussian-distributed and the 1/e² beam diameter on the animal skin surface was fixed at 0.94 and 0.88 cm along horizontal and vertical directions. Damage lesion determinations were performed at 1- and 24-hour post-exposure. The probit analysis was employed to establish the ED₅₀ values. The ED₅₀ expressed in peak radiant exposure for the Gaussian spot was 4.04 J/cm² at the 24-hour post-exposure. Sufficient margin existed between the damage threshold and MPE from the current laser safety standard. The obtained data may contribute to the knowledge base for refinement of laser safety standard in the wavelength range of 2.6-1000 µm.