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Postpartum-Acquired Hemophilia A Presenting as Hemoperitoneum: A Case Report
Khalid Azam1, Zainab Batool1, Ayesha Malik2
1Medicine, Combined Military Hospital Lahore Medical College and Institute of Dentistry, Lahore, PAK.
Cureus
|January 7, 2021
Summary
Acquired hemophilia A (AHA) is a rare bleeding disorder caused by autoantibodies to factor VIII. Early diagnosis and inhibitor eradication are crucial for managing this condition, which can be life-threatening if missed.
Area of Science:
- Hematology
- Immunology
- Obstetrics
Background:
- Acquired hemophilia A (AHA) is a rare but serious bleeding disorder.
- It results from autoantibodies targeting coagulation factor VIII (FVIII).
- AHA presents with isolated abnormalities in the activated partial thromboplastin time (aPTT).
Observation:
- A case report of a 26-year-old woman is presented.
- The patient experienced hemoperitoneum in the postpartum period.
- This complication occurred after a lower segment Caesarean section (LSCS).
Findings:
- The patient's presentation mimicked other postpartum complications.
- Diagnosis of AHA was confirmed through specific coagulation factor assays.
- The intrinsic coagulation pathway was identified as defective.
Implications:
- Undiagnosed AHA carries a high mortality risk.
- Prompt recognition and management are essential.
- Eradication of acquired FVIII inhibitors is key to successful treatment and patient survival.
