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Mass screening vs lockdown vs combination of both to control COVID-19: A systematic review
Nadya Johanna1, Henrico Citrawijaya1, Grace Wangge2
1Faculty of Medicine, Universitas Indonesia, Jakarta.
Abstract:
Coronavirus disease 2019 (COVID-19) is a global pandemic. Non-pharmacological interventions, such as lockdown and mass testing, remain as the mainstay of control measures for the outbreak. We aim to evaluate the effectiveness of mass testing, lockdown, or a combination of both to control COVID-19 pandemic. A systematic search on 11 major databases was conducted on June 8, 2020. This review is registered in Prospero (CRD420201 90546). We included primary studies written in English which investigate mass screening, lockdown, or a combination of both to control and/or mitigate the COVID-19 pandemic. There are four important outcomes as selected by WHO experts for their decision- making process: incident cases, onward transmission, mortality, and resource use. Among 623 studies, only 14 studies met our criteria. Four observational studies were rated as strong evidence and ten modelling studies were rated as moderate evidence. Based on one modelling study, mass testing reduced the total infected people compared to no mass testing. For lockdown, ten studies consistently showed that it successfully reduced the incidence, onward transmission, and mortality rate of COVID-19. A limited evidence showed that a combination of lockdown and mass screening resulted in a greater reduction of incidence and mortality rate compared to lockdown only. However, there is not enough evidence on the effectiveness of mass testing only.
Insights
Lockdowns effectively reduced COVID-19 spread, incidence, and mortality. Combining lockdowns with mass testing may offer greater benefits, but more research is needed on mass testing alone.
Area of Science:
- Public Health
- Epidemiology
- Infectious Disease Control
Background:
- The COVID-19 pandemic necessitated non-pharmacological interventions for control.
- Lockdown and mass testing are key strategies to mitigate outbreaks.
Purpose of the Study:
- To evaluate the effectiveness of mass testing, lockdown, or a combination of both in controlling the COVID-19 pandemic.
- To analyze impacts on incident cases, onward transmission, mortality, and resource use.
Main Methods:
- Systematic search of 11 major databases conducted on June 8, 2020.
- Inclusion of 14 primary studies (4 observational, 10 modeling) in English.
- Focus on studies investigating mass screening, lockdown, or combined interventions for COVID-19.
Main Results:
- Lockdown consistently reduced COVID-19 incidence, transmission, and mortality.
- Mass testing showed potential in reducing infected individuals, based on one modeling study.
- Limited evidence suggests combined lockdown and mass screening yield greater reductions than lockdown alone.
Conclusions:
- Lockdowns are a proven effective intervention for COVID-19 control.
- Combined strategies may enhance public health outcomes, warranting further investigation.
- Insufficient evidence exists regarding the sole effectiveness of mass testing.
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