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Related Concept Videos

Obesity01:24

Obesity

933
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Bone Disorders01:29

Bone Disorders

4.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.4K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.4K
Bone Remodeling01:40

Bone Remodeling

39.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Related Experiment Video

Updated: Nov 22, 2025

Osteoclast Derivation from Mouse Bone Marrow
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Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

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Obesity and Bone Health: A Complex Link.

Jing Hou1, Chen He1, Wenzhen He1

  • 1Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China.

Frontiers in Cell and Developmental Biology
|January 7, 2021
PubMed
Summary

Obesity impacts bone health through complex mechanisms involving various fat tissues and their secretions. Bone health in obesity is influenced by factors like mechanical loading, obesity type, and individual characteristics.

Keywords:
adipose tissuebone healthbone remodelingbone-related diseasesobesity

Related Experiment Videos

Last Updated: Nov 22, 2025

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

24.6K

Area of Science:

  • Endocrinology
  • Bone Biology
  • Metabolic Health

Background:

  • The relationship between obesity and skeletal health is complex and yields inconsistent findings.
  • Obesity influences bone health via body weight, fat mass, inflammatory cytokines, and the bone marrow microenvironment.

Purpose of the Study:

  • To review the effects of adipokines from white adipose tissue on bone cells.
  • To examine the interplay between brown adipose tissue, bone marrow adipose tissue, and bone metabolism.
  • To synthesize evidence on adipose tissue distribution's impact on bone mass and related diseases.

Main Methods:

  • Literature review focusing on adipokines, adipose tissue depots, and bone metabolism.
  • Analysis of studies correlating obesity types and distribution with bone health outcomes.
  • Examination of bone metabolism changes in anorexia nervosa and type 2 diabetes.

Main Results:

  • Adipokines secreted by white adipose tissue significantly affect bone cells.
  • Interactions between brown adipose tissue, bone marrow adipose tissue, and bone metabolism are crucial.
  • Adipose tissue distribution and obesity type are linked to bone mass and disease risk.

Conclusions:

  • Skeletal response to obesity is multifaceted, influenced by mechanical loading, obesity type, fat distribution, and host factors.
  • Gender, age, bone site, and cytokine profiles are critical determinants of bone health in obesity.
  • Understanding these complex interactions is vital for managing bone health in metabolic disorders.