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Updated: Nov 22, 2025

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
Published on: August 12, 2015
BRCA1/2 Mutation Status Impact on Autophagy and Immune Response: Unheralded Target
Susan Morand1, Laura Stanbery2, Adam Walter3
1Department of Internal Medicine, University of Toledo, Toledo, OH, USA.
Abstract:
BRCA1 and possibly BRCA2 proteins may relate to the regulation of autophagy. Autophagy plays a key role in immune response from both a tumor and immune effector cell standpoint. In cells with BRCA mutations, increased autophagy leads to elevated expression of major histocompatibility complex class II but may cause subclonal neoantigen presentation, which may impair the immune response related to clonal neoantigen visibility. We review evidence of BRCA1/2 regulation of autophagy, immune response, and antigen presentation.
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