Forensic characterization and genetic evaluation in the Central Indian population using 27 Y-STRs

Area of Science:

• Forensic Genetics
• Population Genetics
• Human Genetics

Background:

• Forensic characterization and genetic evaluation of the Central Indian population.
• Study involved 539 randomly selected unrelated adult healthy individuals.

Purpose of the Study:

• To characterize and genetically evaluate the Central Indian population using Y-STR markers.
• To enrich the Y STR data bank with novel genetic information.
• To assess the utility of Y-STRs for forensic DNA analysis in this population.

Main Methods:

• Utilized a multiplex of 27 Y-STR loci (Yfiler™ Plus kit).
• Analyzed genetic profiles from 533 individuals after removing samples with large deletions or tri-allelic patterns.
• Haplotype analysis was performed on the processed samples.

Main Results:

• Generated 507 haplotypes from 533 individuals, with 482 unique haplotypes identified.
• Calculated key forensic parameters: Gene Diversity (GD) of 0.669 and Discrimination Capacity (DC) of 0.951 for the Y-STR loci.
• Identified 6 samples with large deletion and tri-allelic patterns.

Conclusions:

• The study provides a comprehensive Y-STR dataset for the Central Indian population.
• The obtained genetic data enhances the Y STR database for forensic applications.
• Y-STR markers demonstrate high discriminatory power for individual identification and population genetic studies in this region.