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Update on the Inflammatory Hypothesis of Coronary Artery Disease

Julia Boland1, Carlin Long2

  • 1Department of Internal Medicine, George Washington University Hospital, Washington, DC, USA. jboland@gwu.edu.

Current Cardiology Reports
|January 7, 2021
PubMed

Insights

Inflammation plays a key role in coronary artery disease (CAD) progression. Recent trials highlight cost-effective anti-inflammatory therapies as the future of preventative CAD treatment.

Area of Science:

  • Cardiovascular Medicine
  • Immunology

Background:

  • Coronary artery disease (CAD) pathogenesis involves inflammation alongside cholesterol imbalance.
  • Emerging evidence supports the inflammatory hypothesis of CAD.

Purpose of the Study:

  • To review recent clinical trials supporting the inflammatory hypothesis of CAD.
  • To discuss the future of preventative CAD treatment focusing on cost-effective anti-inflammatory therapies.

Main Methods:

  • Review of key clinical trials including CANTOS, CIRT, COLCOT, and LoDoCo2.
  • Analysis of anti-inflammatory and anti-cytokine agents in CAD prevention.

Main Results:

  • Canakinumab (anti-interleukin-1β) reduced cardiovascular events but is not cost-effective.
  • Colchicine trials (COLCOT, LoDoCo2) and CIRT provide further support for inflammation's role.
  • Cost-effective anti-inflammatory treatments are needed for preventative CAD therapy.

Conclusions:

  • Inflammation is a critical driver of CAD progression.
  • Targeting inflammation with cost-effective therapies represents a promising future for CAD prevention.
  • Further research into specific anti-inflammatory targets is warranted.
Abstract

Keywords:
AtherosclerosisCoronary artery diseaseCytokinesInflammationInflammatory hypothesis

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