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Anti-aging Effects of Antioxidant Rare-Earth Orthovanadate Nanoparticles in Wistar Rats
Yuri V Nikitchenko1, Vladimir K Klochkov2, Nataliya S Kavok3
1Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, 61022, Ukraine.
Biological Trace Element Research
|January 7, 2021
Summary
Rare-earth orthovanadate nanoparticles (OV NPs) show age-related benefits by improving antioxidant defense and stabilizing oxidative balance. Their protective effects involve direct antioxidant action and modulating bioenergetic processes, enhancing health span.
Area of Science:
- Nanomedicine
- Biochemistry
- Gerontology
Background:
- Rare-earth orthovanadate nanoparticles (OV NPs) exhibit beneficial age-related effects on redox balance.
- Previous studies indicated OV NPs' impact on liver and blood in Wistar rats.
- The direct link between OV NPs' redox activity and their protective capabilities required further investigation.
Purpose of the Study:
- To comparatively assay the antiradical, antioxidant, and membrane-protective properties of various rare-earth orthovanadate nanoparticles (OV NPs).
- To elucidate the mechanisms underlying the beneficial effects of OV NPs in an aged organism.
- To evaluate the impact of OV NPs on mitochondrial bioenergetics and the GSH-dependent antioxidant system.
Main Methods:
- Comparative analysis of antioxidant and membrane-protective properties of GdYVO4/Eu3+ NPs, GdVO4/Eu3+ NPs, and LaVO4/Eu3+ NPs in vitro.
- Assessment of OV NPs' effects on mitochondrial respiration, oxidative phosphorylation, and ATP concentration.
- Evaluation of oxidative balance and GSH signaling in aged rats following prolonged OV NP administration.
Main Results:
- All tested OV NPs demonstrated protective properties, with extra-small GdYVO4/Eu3+ NPs showing the weakest antioxidant efficacy.
- OV NPs reduced mitochondrial respiration, oxidative phosphorylation, and ATP concentration, particularly the extra-small NPs.
- Prolonged administration of GdVO4/Eu3+ NPs improved oxidative balance in aged rats, maintaining GSH signaling comparable to younger animals.
Conclusions:
- The beneficial effects of OV NPs in aged organisms are attributed to both direct antioxidant activity and the suppression of bioenergetic processes.
- Triggering of the GSH-dependent antioxidant system by OV NPs plays a crucial role in their protective influence.
- Enhanced antioxidant defense and stabilized oxidative balance through prolonged OV NP usage can increase health span and survival.
