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Chronic urticaria in children under 15 years of age: Clinical experience beyond the clinical trials

Oriol Corral-Magaña1, José Antonio Gil-Sánchez2, Catalina Bover-Bauzá3

  • 1Department of Dermatology, Hospital Universitari Son Espases, Palma de Mallorca, Spain.

Pediatric Dermatology
|January 7, 2021
PubMed

Insights

Pediatric chronic urticaria (CU) in Spain presented similarly to adult cases, with most children responding well to H1-antihistamines. Further research is needed to establish specific pediatric treatment guidelines.

Area of Science:

  • Pediatric Dermatology
  • Allergy and Immunology

Background:

  • Chronic urticaria (CU) is a challenging condition in children.
  • Understanding its clinical profile and management in pediatric populations is crucial.

Purpose of the Study:

  • To describe the clinical characteristics, management strategies, and outcomes of pediatric patients diagnosed with chronic urticaria.
  • To evaluate the effectiveness of current treatment protocols in children.

Main Methods:

  • Retrospective study of children under 15 years diagnosed with CU between 2014 and 2019.
  • CU defined as persistent wheals and/or angioedema for over 6 weeks.
  • Data collected on patient demographics, triggers, comorbidities, and treatment responses.

Main Results:

  • Twenty-nine pediatric patients (mean age 8 years, 17 girls) were included.
  • 31% had a family history of atopy; 41.3% experienced associated angioedema.
  • Most cases responded to standard or doubled doses of H1-antihistamines; omalizumab was effective in refractory cases.

Conclusions:

  • Pediatric CU shares similarities with adult CU, including female predominance and links to atopy.
  • Current treatment guidelines for adults are applied to children, highlighting a need for pediatric-specific assessment tools and treatment strategies.
Abstract

Keywords:
H1-antihistaminesangioedemachronic urticariaomalizumab

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