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Dual recognition element-controlled logic DNA circuit for COVID-19 detection based on exonuclease III and DNAzyme
Jiafeng Pan1, Ying He1, Zhi Liu1
1College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China. tigerzhiliu@126.com.
Chemical Communications (Cambridge, England)
|January 7, 2021
Abstract:
Two fragments of the COVID-19 genome (specific and homologous) were used as two inputs to construct an AND logic gate for COVID-19 detection based on exonuclease III and DNAzyme. The detection sensitivity of the assay can reach fM levels. Satisfactory recovery values were obtained in real sample analysis.
