Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Medullary sponge kidney and hyperparathyroidism.

E Higashihara1, A Munakata, M Hara

  • 1Department of Urology, University of Tokyo, Japan.

Urology
|February 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stress up-regulates oxidative burst in juvenile Chinook salmon leukocytes.

Fish & shellfish immunology·2018
Same author

Evaluation of seasonal and daily changes of plasma thyroxine and cortisol levels in wild masu salmon Oncorhynchus masou, sampled by a Japanese fishing method.

Journal of fish biology·2014
Same author

Seasonal changes in gene expression of corticoid receptors in anadromous and non-anadromous strains of rainbow trout Oncorhynchus mykiss.

Journal of fish biology·2014
Same author

A case of dissecting aortic aneurysm with cystic medial necrosis in systemic lupus erythematosus.

Modern rheumatology·2014
Same author

Survival benefit for patients with colorectal cancer detected by population-based screening program using an immunochemical fecal occult blood test.

International journal of oncology·2011
Same author

Prevention of advanced colorectal cancer by screening using the immunochemical faecal occult blood test: a case-control study.

British journal of cancer·2003

Medullary sponge kidney (MSK) and primary hyperparathyroidism may occur independently. Alkali treatment corrected hypercalciuria in a patient with MSK and renal tubular acidosis.

Area of Science:

  • Nephrology
  • Endocrinology
  • Oncology

Background:

  • Medullary sponge kidney (MSK) is a congenital kidney malformation.
  • Primary hyperparathyroidism is a common endocrine disorder.
  • Renal-leak hypercalciuria is a condition characterized by excessive calcium excretion in the urine.

Observation:

  • A single female patient presented with concurrent MSK, parathyroid adenoma, renal cell carcinoma, and renal-leak hypercalciuria.
  • Parathyroid adenoma removal did not resolve the hypercalciuria.
  • The patient had co-existing renal tubular acidosis (RTA).

Findings:

  • Alkali treatment effectively corrected the renal-leak hypercalciuria in the RTA patient.
  • Renal cell carcinoma developed during the observation period.

Related Experiment Videos

  • Histological confirmation supported the diagnosis of MSK.

    • Implications:

    • This case suggests that MSK and primary hyperparathyroidism can be independent conditions.
    • RTA may play a role in the pathogenesis or persistence of hypercalciuria.
    • The co-occurrence highlights the complex interplay between genetic predisposition, endocrine disorders, and renal pathologies.