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Blood Flow Imaging with Ultrafast Doppler
Published on: October 14, 2020
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A technique for intra-procedural blood velocity quantitation using time-resolved 2D digital subtraction angiography
Carson Hoffman1, Sarvesh Periyasamy2, Colin Longhurst3
1Department of Medical Physics, University of Wisconsin - Madison, 1111 Highland Ave, Madison, WI, 53705, USA.
CVIR Endovascular
|January 7, 2021
Summary
Quantitative 2D digital subtraction angiography (qDSA) accurately measures blood velocity. This validated technique allows for precise, real-time in vivo assessments, improving arterial intervention endpoints.
Area of Science:
- Medical Imaging
- Cardiovascular Imaging
- Interventional Radiology
Background:
- 2D digital subtraction angiography (DSA) is used qualitatively for blood velocity assessment during arterial interventions.
- Quantitative metrics like blood velocity could standardize intervention endpoints.
Purpose of the Study:
- To assess the accuracy and precision of a quantitative 2D DSA (qDSA) technique.
- To determine the feasibility of qDSA for in vivo blood velocity measurements.
Main Methods:
- Developed a qDSA technique to calculate intra-procedural blood velocity.
- Validated in vitro using a bifurcation phantom and ultrasonic flow probe.
- Performed in vivo analysis in swine aorta branches, comparing with 4D Flow MRI.
Main Results:
- In vitro: Strong correlation (Pearson's r = 0.996) between qDSA and flow probe velocities.
- Projection angle and magnification corrections reduced variance to <5%.
- In vivo: Strong correlation (Pearson's r = 0.880) and small bias between qDSA and 4D Flow MRI velocities.
Conclusions:
- The qDSA method provides accurate and precise blood velocity calculations.
- Near real-time measurements are achievable from time-resolved 2D DSAs.
- This technique has potential for standardizing endpoints in angiographic interventions.
