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Epidemiological, molecular, and clinical features of rotavirus infections among pediatrics in Qatar

Shilu Mathew1, Khalid Al Ansari2, Asmaa A Al Thani1,3

  • 1Biomedical Research Center, Qatar University, Doha, Qatar.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|January 7, 2021
PubMed

Insights

Rotavirus (RV) infections are common in children under three in Qatar, with G3P[8] genotypes causing the most severe diarrhea and vomiting. This study highlights the diverse RV strains circulating in Qatar due to its multinational population.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Acute gastroenteritis (AGE) is a significant global health issue, particularly in children.
  • Rotavirus (RV) is a primary etiological agent responsible for severe pediatric diarrhea worldwide.
  • Understanding circulating RV genotypes and their clinical impact is crucial for effective disease management and vaccine strategies.

Purpose of the Study:

  • To investigate the prevalence of circulating rotavirus genotypes in Qatar.
  • To analyze the association between RV genotypes, demographic factors, and clinical manifestations in children.
  • To identify dominant RV strains and their characteristics within the Qatari population.

Main Methods:

  • Collection and analysis of 231 RV-positive fecal samples from children with AGE over three years (June 2016-June 2019).
  • Amplification and sequencing of VP4 and VP7 genes for genotype determination.
  • Phylogenetic analysis using MEGA7.0 and statistical comparisons using Pearson's chi-squared test.

Main Results:

  • RV infections were most prevalent in children aged 1-3 years (49%) and more frequent in males (1.4:1 ratio).
  • Common genotypes identified were G3P[8] (30.8%), G2P[8] (12.3%), G4P[8] (11.7%), and G1P[8] (10.4%).
  • The G3P[8] genotype was associated with the most severe clinical illness, including frequent diarrhea and vomiting, and showed higher incidence in Qatari subjects.

Conclusions:

  • The multinational population of Qatar contributes to a wide diversity of circulating RV genotypes.
  • G3P[8] emerged as the most prevalent genotype associated with severe illness, differing from regional and global patterns.
  • Findings underscore the importance of continuous surveillance of RV genotypes and their clinical impact in Qatar.

Keywords:
Age-specificGenotypingRotavirusVaccination

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