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Adiponectin, Leptin and Cardiovascular Disorders.

Shangang Zhao¹, Christine M Kusminski¹, Philipp E Scherer^1,2

¹Touchstone Diabetes Center, Department of Internal Medicine (S.Z., C.M.K., P.E.S.), The University of Texas Southwestern Medical Center, Dallas.

Circulation Research

|January 7, 2021

Summary

Adipose tissue hormones leptin and adiponectin are crucial for cardiovascular health. Paradoxically, high levels of both are linked to cardiovascular disorders, suggesting new therapeutic targets.

Keywords:

adiponectin cardiovascular diseases hypoadiponectinemia leptin obesity

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Published on: July 21, 2023

Area of Science:

Endocrinology and Metabolism
Cardiovascular Research
Adipose Tissue Biology

Background:

Adipose tissue is an endocrine organ secreting leptin and adiponectin.
Obesity-associated changes in leptin and adiponectin levels are linked to cardiovascular disease.
Normal physiological levels of these hormones are vital for cardiovascular function.

Purpose of the Study:

To review current knowledge on leptin, adiponectin, and cardiovascular disorders.
To elucidate the paradoxical roles of elevated leptin and adiponectin in cardiovascular disease.
To explore therapeutic strategies involving leptin reduction and adiponectin/leptin ratio modulation.

Main Methods:

Literature review of recent advancements in adipokine research.
Analysis of mechanisms underlying the leptin-adiponectin paradox in cardiovascular pathology.
Exploration of potential clinical applications for modulating adipokine levels.

Main Results:

Established roles of leptin and adiponectin in adipose-mediated tissue crosstalk.
Identified hyperleptinemia and hypoadiponectinemia as cardiovascular risk biomarkers.
Highlighted a paradox of high leptin and adiponectin levels in cardiovascular disorder pathogenesis.

Conclusions:

Leptin and adiponectin signaling is essential for maintaining cardiovascular homeostasis.
The emerging paradox of elevated leptin and adiponectin warrants further investigation.
Modulating adiponectin/leptin ratios and selective leptin reduction may offer therapeutic benefits for cardiovascular disorders.