Related Experiment Video
Updated: Nov 22, 2025

Horizontal Hippocampal Slices of the Mouse Brain
Published on: September 22, 2020
Anatomy and White Matter Connections of the Parahippocampal Gyrus
Yueh-Hsin Lin1, Vukshitha Dhanaraj1, Alana E Mackenzie1
1Centre for Minimally Invasive Neurosurgery Prince of Wales Private Hospital, Sydney, Australia.
Background:
The parahippocampal gyrus is understood to have a role in high cognitive functions including memory encoding and retrieval and visuospatial processing. A detailed understanding of the exact location and nature of associated white tracts could significantly improve postoperative morbidity related to declining capacity. Through diffusion tensor imaging-based fiber tracking validated by gross anatomic dissection as ground truth, we have characterized these connections based on relationships to other well-known structures.
Methods:
Diffusion imaging from the Human Connectome Project for 10 healthy adult controls was used for tractography analysis. We evaluated the parahippocampal gyrus as a whole based on connectivity with other regions. All parahippocampal gyrus tracts were mapped in both hemispheres, and a lateralization index was calculated with resultant tract volumes.
Results:
We identified 2 connections of the parahippocampal gyrus: inferior longitudinal fasciculus and cingulum. Lateralization of the cingulum was detected (P < 0.05).
Conclusions:
The parahippocampal gyrus is an important center for memory processing. Subtle differences in executive functioning following surgery for limbic tumors may be better understood in the context of the fiber-bundle anatomy highlighted by this study.
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