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An update on the role of miR-124 in the pathogenesis of human disorders

Soudeh Ghafouri-Fard1, Hamed Shoorei2, Zahra Bahroudi3

  • 1Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 7, 2021
PubMed

Insights

MicroRNA-124 (miR-124) plays a key role in nervous system development and disease. This study details miR-124

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • MicroRNA-124 (miR-124) is abundant in the brain and involved in nervous system development.
  • Aberrant miR-124 expression is linked to neurological disorders like Alzheimer's, Parkinson's, and stroke.
  • miR-124 also impacts cardiovascular diseases and various human cancers.

Purpose of the Study:

  • To elucidate the multifaceted role of miR-124 in both malignant and non-malignant conditions.
  • To consolidate current understanding of miR-124's involvement in disease pathogenesis.

Main Methods:

  • Literature review and analysis of existing studies on miR-124.
  • Examination of miR-124 expression patterns in various disease models.
  • Correlation analysis of miR-124 levels with disease progression and outcomes.

Main Results:

  • miR-124 is significantly dysregulated in numerous neurological and cardiovascular diseases.
  • Downregulation of miR-124 is a common feature in many cancers, including colorectal, breast, and gastric cancers.
  • Upregulation of miR-124 has been observed in specific cancer types, indicating complex regulatory roles.

Conclusions:

  • MicroRNA-124 is a critical regulator implicated in a wide spectrum of human diseases.
  • Understanding miR-124's dual role in cancer pathogenesis is crucial for therapeutic strategies.
  • Further research into miR-124's functions can unlock new diagnostic and therapeutic targets.
Keywords:
CancerExpressionMarkermiR-124

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