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Updated: Nov 22, 2025

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration
Published on: November 23, 2019
Yongbin Zhang1, Lifei Zhang2, Laurence E Court2
1Department of Radiation Physics, the University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA; Department of Radiation Oncology, Proton Therapy Center, University of Cincinnati Medical Center, 7777 Yankee Road, Liberty Township, 45044, USA.
This study introduces a novel tissue-specific regularization for deformable image registration, improving accuracy in medical imaging by accounting for different tissue motions. The enhanced method significantly reduces landmark registration errors compared to the original Demons algorithm.
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