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β1-Adrenoceptor antibodies induce PPCM via inhibition of PGC-1α related pathway

Yuan Zhang1, Jia Liu1, Linying Shi1

  • 1Department of Cardiology & Beijing Key Laboratory of Hypertension Disease, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, PR China.

Scandinavian Cardiovascular Journal : SCJ
|January 8, 2021
PubMed

Insights

Elevated beta-1 adrenoceptor (β1AR) antibodies in postpartum rats led to peripartum cardiomyopathy (PPCM) symptoms. This suggests β1AR antibodies may inhibit peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) signaling, contributing to PPCM development.

Area of Science:

  • Cardiology
  • Immunology
  • Molecular Biology

Background:

  • Peripartum cardiomyopathy (PPCM) is a severe pregnancy-associated heart condition with unclear causes.
  • Elevated beta-1 adrenoceptor (β1AR) antibodies are implicated in PPCM pathogenesis.

Purpose of the Study:

  • To investigate the role of β1AR antibodies in inducing PPCM.
  • To explore the impact of β1AR antibodies on cardiac function and molecular pathways.

Main Methods:

  • Developed an autoimmune model in postpartum Wistar rats by injecting β1AR antigen peptide.
  • Assessed cardiac function via echocardiography.
  • Measured β1AR antibody levels, myocyte apoptosis, and expression of PGC-1α and related proteins.

Main Results:

  • Autoimmune rats developed PPCM symptoms with increased β1AR antibodies.
  • Decreased expression of mitochondrial regulator PGC-1α and VEGF observed.
  • Increased caspase 3 expression and left ventricular myocyte apoptosis rates noted.

Conclusions:

  • Increased β1AR antibodies contribute to PPCM development in an autoimmune rat model.
  • Inhibition of the PGC-1α pathway by β1AR antibodies is a potential mechanism for PPCM.
Abstract

Keywords:
Peripartum cardiomyopathyapoptosisperoxisome proliferator-activated receptor γ coactivator-1αvascular endothelial growth factorβ1-adrenoceptor antibodies

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