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Related Experiment Videos

Effects of testosterone therapy for pubertal delay.

D M Wilson1, J Kei, R L Hintz

  • 1Department of Pediatrics, Stanford (Calif) University 94305.

American Journal of Diseases of Children (1960)
|January 1, 1988
PubMed
Summary

A brief testosterone enanthate course significantly improved height z scores and sexual maturation in males with delayed puberty. Most patients were satisfied with the treatment outcomes.

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Area of Science:

  • Endocrinology
  • Pediatrics

Background:

  • Delayed puberty is a common concern in pediatric endocrinology.
  • Testosterone therapy is a potential treatment for pubertal delay.

Purpose of the Study:

  • To evaluate the efficacy of a brief testosterone enanthate regimen on pubertal advancement and final adult height in males with delayed puberty.

Main Methods:

  • A retrospective review of 50 male patients with delayed puberty treated with testosterone enanthate (200 mg IM every 3 weeks for 4 doses).
  • Comparison with a control group of 38 untreated subjects with similar baseline characteristics.
  • Assessment of height z score, sexual maturation index, and predicted adult height.

Main Results:

  • The testosterone-treated group showed significantly greater increases in height z score and sexual maturation index at 4 months.

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  • The improvement in sexual maturation index persisted at 12 months.
  • No significant difference in absolute height z score was observed in subjects over 17 years old.

    • Conclusions:

    • A brief course of testosterone enanthate effectively accelerates pubertal development in males with delayed puberty.
    • The treatment is well-tolerated and associated with high patient satisfaction.
    • Long-term effects on final adult height require further investigation, particularly in older adolescents.