Related Experiment Video

Updated: Nov 22, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.6K

Prognostic value of pro-adrenomedullin and copeptin in acute infective endocarditis

Rosa Zampino1,2, Domenico Iossa3, Maria Paola Ursi1

  • 1Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.

BMC Infectious Diseases
|January 8, 2021
PubMed

Insights

Prognostic biomarkers pro-adrenomedullin and copeptin may predict worse outcomes in infective endocarditis (IE). Procalcitonin (PCT) indicates Staphylococcus aureus infection, while C-reactive protein (CRP) signals embolic risk.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Biomarker Research

Background:

  • Infective endocarditis (IE) poses a significant mortality risk, with prognosis challenging to predict using clinical data alone.
  • Biomarkers have demonstrated utility in managing various cardiac conditions.
  • This study investigated the prognostic value of procalcitonin (PCT), pro-adrenomedullin (pro-ADM), and copeptin in IE.

Purpose of the Study:

  • To evaluate the prognostic significance of PCT, pro-ADM, and copeptin in patients with IE.
  • To explore the relationship between these biomarkers, disease characteristics, and the established biomarker C-reactive protein (CRP).

Main Methods:

  • A retrospective analysis of 196 patients diagnosed with definite IE.
  • Collection and analysis of clinical, laboratory, and echocardiography data, including comorbidities.
  • Measurement of PCT, pro-ADM, and copeptin from plasma samples collected upon admission during the acute disease phase.

Main Results:

  • Pro-ADM and copeptin levels were elevated in older patients and those with chronic kidney disease.
  • Pro-ADM independently predicted hospital mortality (OR 3.29), and copeptin independently predicted 1-year mortality (OR 2.55).
  • High PCT levels correlated strongly with Staphylococcus aureus infection (p=0.001), and CRP was associated with embolic events (p=0.003).

Conclusions:

  • Distinct biomarkers are associated with specific outcomes in IE.
  • Pro-ADM and copeptin may indicate a poorer prognosis upon hospital admission, identifying patients needing intensive management.
  • CRP serves as a cost-effective marker for embolic risk, while high PCT suggests Staphylococcus aureus etiology.
Abstract

Keywords:
BiomarkersHeart failureHeart valve diseaseMortalityOrgan dysfunction

More Related Videos

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.6K
A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay10:12

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

Published on: August 8, 2013

16.9K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
346
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
96
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
563
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
95
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
150
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
145