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Neuron-specific enolase in comatose children.

T Nara1, H Nozaki, Y Nakae

  • 1Division of Neurology, Children's Medical Center, Saitama, Japan.

American Journal of Diseases of Children (1960)
|February 1, 1988
PubMed
Summary
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Neuron-specific enolase levels in cerebrospinal fluid and serum correlate with brain damage severity in children. Elevated neuron-specific enolase indicates worse outcomes, suggesting its use as a prognostic marker.

Area of Science:

  • Neurology
  • Biochemistry
  • Pediatrics

Background:

  • Comatose children with acute encephalitis, encephalopathy, or Reye's syndrome often experience significant neurological damage.
  • Assessing the extent of neuronal injury and predicting patient prognosis in these conditions is clinically challenging.

Purpose of the Study:

  • To investigate the utility of neuron-specific enolase (NSE) as a biomarker for neuronal damage.
  • To correlate NSE levels in cerebrospinal fluid (CSF) and serum with the severity of brain injury and patient outcomes.

Main Methods:

  • Sequential measurements of neuron-specific enolase were conducted in CSF and serum samples.
  • The study included 20 comatose pediatric patients diagnosed with acute encephalitis, acute encephalopathy, or Reye's syndrome.

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Main Results:

  • Neuron-specific enolase activity levels demonstrated a direct correlation with the degree of brain damage observed in the patients.
  • Patients with neuron-specific enolase levels exceeding 80 ng/mL exhibited more severe impairment or unfortunately succumbed to their condition.

Conclusions:

  • Neuron-specific enolase serves as a valuable indicator for assessing the extent of neuronal damage in critically ill children.
  • NSE measurement can aid in predicting the prognosis for children suffering from acute encephalitis, encephalopathy, or Reye's syndrome.