Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Screening programs for congenital hypothyroidism. How can they be improved?

D B Allen1, S A Hendricks, J Sieger

  • 1Department of Pediatrics, University of Wisconsin, Madison.

American Journal of Diseases of Children (1960)
|February 1, 1988
PubMed
Summary

High-sensitivity newborn screening for congenital hypothyroidism yields many false positives. Physician management varies, delaying diagnosis and treatment, impacting infant outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lack of association between gestational age adjusted TSH percentiles and neurodevelopmental outcomes among preterm infants.

Journal of neonatal-perinatal medicine·2022
Same author

Use of Gonadotropin-Releasing Hormone Analogs in Children: Update by an International Consortium.

Hormone research in paediatrics·2019
Same author

GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults.

European journal of endocrinology·2015
Same author

Familial and individual predictors of obesity and insulin resistance in urban Hispanic children.

Pediatric obesity·2015
Same author

Use of the modified Delphi technique to identify and rate home injury hazard risks and prevention methods for young children.

Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention·2006
Same author

Validating self reported home safety practices in a culturally diverse non-inner city population.

Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention·2006

Area of Science:

  • Neonatal screening
  • Endocrinology
  • Public health

Background:

  • High-sensitivity neonatal screening for congenital hypothyroidism is widely implemented.
  • Low specificity leads to frequent false-positive results, posing clinical, economic, and medicolegal challenges for primary care physicians.

Purpose of the Study:

  • To assess physician management of infants with elevated newborn screening thyrotropin values.
  • To identify challenges and potential improvements in congenital hypothyroidism screening programs.

Main Methods:

  • Survey of 154 physicians managing Wisconsin-born infants with the highest newborn-screen thyrotropin values over two years.

Main Results:

  • Confirmation of normal thyroid function is often delayed beyond six weeks.

Related Experiment Videos

  • Significant variation exists in therapeutic goals for confirmed hypothyroidism.
  • Physicians express a preference for autonomous management of congenital hypothyroidism.

    • Conclusions:

    • Modifications to screening programs, including central confirmatory testing and decision support tools, are proposed.
    • Suggested improvements aim to enhance the long-term outcomes for infants identified with congenital hypothyroidism.