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Related Experiment Videos

Fatal amiodarone hepatoxicity.

N H Gilinsky1, G W Briscoe, C S Kuo

  • 1Department of Medicine, Albert B. Chandler Medical Center, University of Kentucky, Lexington.

The American Journal of Gastroenterology
|February 1, 1988
PubMed
Summary
This summary is machine-generated.

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Amiodarone, an antiarrhythmic drug, can cause rare but severe liver disease. Even after stopping amiodarone, liver damage may not resolve if it becomes irreversible.

Area of Science:

  • Cardiology
  • Hepatology
  • Pharmacology

Background:

  • Amiodarone is an effective antiarrhythmic medication.
  • Clinically significant amiodarone-induced liver injury (DILI) is considered rare.
  • Long-term amiodarone use can lead to various adverse effects.

Observation:

  • A patient developed muscle weakness, hepatomegaly, and ascites after 28 months of amiodarone treatment.
  • The patient's condition worsened despite amiodarone withdrawal.
  • Postmortem liver biopsy revealed necrosis, fibrosis, hyalin, and phospholipid-laden lysosomal lamellar bodies.

Findings:

  • Amiodarone can cause severe, irreversible liver damage.
  • Resolution of hepatic dysfunction is not guaranteed upon amiodarone cessation if damage is advanced.

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  • The study highlights a rare but critical adverse effect of amiodarone therapy.

    • Implications:

    • Patients on long-term amiodarone require indefinite monitoring of liver function.
    • Monitoring should include hepatic enzyme levels and serum albumin concentration.
    • Early detection and intervention are crucial for managing potential amiodarone-induced liver injury.