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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Whole Body Regeneration01:33

Whole Body Regeneration

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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Related Experiment Video

Updated: Nov 22, 2025

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
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Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

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Precision regenerative medicine.

Amy L Lightner1,2,3, Timothy Chan4,5

  • 1Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA. Lightna@ccf.org.

Stem Cell Research & Therapy
|January 8, 2021
PubMed
Summary
This summary is machine-generated.

Precision cell therapy offers a personalized approach to regenerative medicine, moving beyond generic treatments. This tailored strategy promises enhanced efficacy for individual patients and specific conditions.

Keywords:
Individualized regenerative medicineMesenchymal stem cellsPrecision cell therapy

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Area of Science:

  • Regenerative Medicine
  • Cellular Therapy
  • Precision Medicine

Background:

  • Precision medicine is common in other fields but not yet in regenerative medicine.
  • Current regenerative therapies often use a one-size-fits-all approach, like generic mesenchymal stem cell therapy.
  • Some conditions may not benefit from generic mesenchymal stem cell therapy.

Purpose of the Study:

  • To introduce the concept of precision cell-based therapy in regenerative medicine.
  • To highlight the potential of targeted and engineered therapies for improving treatment efficacy.
  • To address the limitations of current generic approaches.

Main Methods:

  • Discussion of targeted and engineered cellular and acellular therapies.
  • Exploration of autologous therapies tailored to individuals or disease states.
  • Consideration of engineered cell therapy as an alternative to generic approaches.

Main Results:

  • Targeted and engineered therapies could significantly improve the efficacy of autologous treatments.
  • Personalized cell therapy can overcome the limitations of generic approaches.
  • Engineered cell therapy offers a solution to the 'one-size-fits-all' model.

Conclusions:

  • The future of regenerative medicine is precision cell-based therapy.
  • Tailored cellular therapies are essential for advancing the field.
  • Individualized approaches will enhance patient outcomes in regenerative medicine.