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Related Concept Videos

Necrosis01:16

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Updated: Nov 22, 2025

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Spontaneous Necrotizing Fasciitis.

Patrick J Rogers1, Brent M Lewis2, Mihir Odak3

  • 1Emergency Medicine, Jersey Shore University Medical Center, Neptune City, USA.

Cureus
|January 8, 2021
PubMed
Summary
This summary is machine-generated.

Necrotizing soft tissue infections can present atypically. The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score may not rule out these severe infections, necessitating surgical debridement for diagnosis.

Keywords:
necrotizing fascitissoft tissue infectionsurgical debridement

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Area of Science:

  • Infectious Diseases
  • Surgical Pathology

Background:

  • Necrotizing soft tissue infections (NSTIs) are severe bacterial infections.
  • They typically result from direct bacterial inoculation into subcutaneous tissues.

Observation:

  • A middle-aged male presented with swelling but no tenderness, initially misdiagnosed as an allergic reaction.
  • Imaging revealed extensive fluid in the fascial planes of the right chest wall.

Findings:

  • The patient was diagnosed with severe necrotizing fasciitis requiring surgical debridement.
  • The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score demonstrated low sensitivity in this case.

Implications:

  • This case highlights an atypical presentation of necrotizing fasciitis.
  • It underscores the limitations of the LRINEC score in ruling out NSTIs.
  • Prompt surgical debridement is critical for managing necrotizing fasciitis, given its high mortality rate.