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Updated: Nov 22, 2025

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
C-Reactive Protein +1444C/T Polymorphism Is Associated with the Susceptibility to Pulmonary Tuberculosis
Yuzhong Xu1, Minggang Cheng1, Xiong Wang2
1Department of Clinical Laboratory, Shenzhen Baoan Hospital, Southern Medical University, Shenzhen 518000, China.
Objective:
The T allele of C-reactive protein (CRP) +1444C/T (rs1130864) polymorphism was associated with increased risk for some inflammatory conditions. The objective of the study was to explore the association between the CRP +1444C/T polymorphism with the susceptibility to pulmonary tuberculosis (PTB) in a Chinese population.
Methods:
This case-control study enrolled 480 PTB patients and 480 healthy controls. The CRP +1444C/T polymorphism was determined using Sanger sequencing. The odds ratio (OR) and 95% confidence interval (CI) were assessed to examine the strength of genetic correlation.
Results:
The genotype and allele frequencies of PTB patients differed from controls (CT vs. CC, OR = 1.924, 95% CI: 1.099-3.371, adjusted P value = 0.022; T vs. C, OR = 1.884, 95% CI: 1.085-3.273, adjusted P value = 0.024). Stratified analysis by sex found that PTB patients' genotype and allele frequencies differed from controls in the male subgroup but not the female subgroup.
Conclusion:
In conclusion, the minor T allele of CRP +1444C/T polymorphism was associated with increased PTB risk.
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