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Gastrosphincter of Oddi reflex
T H Webb1, K D Lillemoe, H A Pitt
1Surgical Service, Baltimore Veterans Administration Medical Center, MD.
American Journal of Surgery
|February 1, 1988
Summary
Gastric distention significantly increases sphincter of Oddi motility via a cholinergically mediated reflex in prairie dogs. This finding is crucial for accurate biliary manometry during procedures.
Area of Science:
- Gastroenterology
- Physiology
- Digestive System Research
Background:
- Gastric distention is known to trigger gallbladder contraction and secretions.
- Gallbladder distention influences sphincter of Oddi motility.
- Gastric distention can occur during biliary manometry procedures.
Purpose of the Study:
- To investigate the effect of gastric distention on sphincter of Oddi motility.
- To determine if a reflex exists between gastric distention and the sphincter of Oddi.
Main Methods:
- Utilized the prairie dog model for experiments.
- Induced gastric distention using acidic and alkaline saline solutions.
- Measured sphincter of Oddi motility parameters (phasic wave frequency, amplitude, motility index) and gallbladder pressure.
- Administered atropine to assess the role of cholinergic pathways.
Main Results:
- Both acidic and alkaline gastric distention significantly increased sphincter of Oddi phasic wave frequency, amplitude, and motility index.
- Gallbladder pressure also increased during gastric distention, confirming the pylorocholecystic reflex.
- Atropine pretreatment abolished these responses, indicating a cholinergically mediated reflex.
Conclusions:
- Gastric distention stimulates sphincter of Oddi motility in prairie dogs, suggesting a novel gastrosphincter of Oddi reflex.
- Gastric distention is a significant confounding variable during endoscopic or operative sphincter of Oddi manometry.
- Controlling for gastric distention is essential for reliable manometric measurements of the sphincter of Oddi.