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Updated: Nov 22, 2025
A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
[Dental complications of the mandibular distraction osteogenesis]
M V Korolenkova1, N V Starikova1
1Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
The Aim Of The Study:
Was to reveal the prevalence of dental abnormalities in children after mandibular distraction osteogenesis (MDO).
Materials And Methods:
The study comprised 75 children aged 5-16 years (42 boys and 33 girls, mean age 9.8±4.2 years) who underwent MDO because of mandible underdevelopment associated with hemifacial microsomia (n=42), Robin syndrome (n=6), Treacher Collins syndrome (n=6), Hallermann-Streiff syndrome (n=1) or acquired conditions (n=16). The mean age at MDO was 6.3±4.4 years. Controls involved 25 children with mandibular underdevelopment (19 with hemifacial microsomis, 4 - with Robin syndrome and 2 with Treacher Collins syndrome, mean age 6.7±3.6 years) receiving orthodontic treatment and with no history of MDO.
Results:
In the study group abnormalities of lower molars were revealed in 42 children from 75. The prevalence of the affected first and second molars was 24.7% and 20.5%, respectively. Every tenth child (9.6%) had disorders of both molars. The risks for the first molar developmental defects after MDO was 12 times higher than in controls (OR=12.4; CI=95%). In 21 children delayed eruption or impaction of the first molars was observed. Second molars abnormalities more often included germs displacement and follicular cyst formation (OR=10.4). The age at MDO was significantly higher in children with no dental abnormalities (p<0.01).
Conclusion:
MDO is associated with significant risk of molars disorders. The younger a child is at MDO the more probable and prominent are the dental complications.
