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Long-Time Phase Correlations Reveal Regulation of Beating Cardiomyocytes
Ohad Cohen1, Ido Nitsan2, Shelly Tzlil2
1Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot 76100, Israel.
Isolated cardiomyocytes exhibit long-term correlations in their beating phase, extending beyond beat-to-beat variability. This suggests cellular regulation mechanisms restore heart cell frequency homeostasis against stochastic perturbations.
Area of Science:
- Cardiology
- Biophysics
- Cellular Physiology
Background:
- Spontaneous cardiomyocyte contractions rely on calcium oscillations.
- Beating phase variability arises from noise and cellular responses affecting oscillation frequency.
Purpose of the Study:
- To investigate long-time correlations in cardiomyocyte beating phase dynamics.
- To explore the underlying cellular regulatory mechanisms responsible for these correlations.
Main Methods:
- Experimental observation of isolated cardiomyocyte beating.
- Analysis of beat-to-beat variability and long-time phase correlations.
- Development of a theoretical model linking correlations to cellular regulation.
Main Results:
- Demonstrated long-time correlations (tens of minutes) in cardiomyocyte beating phase.
- Observed that these correlations exist alongside short-time (1-2 Hz) beat-to-beat variability.
- The theoretical model successfully related these long-time correlations to frequency restoration.
Conclusions:
- Cardiomyocyte beating phase exhibits complex dynamics with both short-term and long-term correlations.
- Cellular regulatory processes actively work to maintain a homeostatic heart cell beating frequency.
- Stochastic perturbations are counteracted by regulatory mechanisms influencing cardiomyocyte contractility.
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