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Updated: Nov 22, 2025
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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
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Tuberculous Scleritis and Multidrug Resistance.
Mamta Agarwal1, Gazal Patnaik2, Shweta Agarwal3
1Uveitis & Cornea Services, Medical Research Foundation, Sankara Nethralaya, Chennai, India.
Ocular Immunology and Inflammation
|January 8, 2021
Summary
Necrotizing sclerokeratitis in a patient with multidrug-resistant tuberculosis poses diagnostic and management challenges. Early detection of drug resistance is crucial to prevent severe outcomes in tuberculous scleritis.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Anterior tuberculous scleritis is a rare but serious ocular manifestation of tuberculosis.
- Diagnosis can be challenging due to non-specific clinical features and the need for microbiological confirmation.
Observation:
- A case of necrotizing sclerokeratitis in a 28-year-old woman with multidrug-resistant tuberculosis is presented.
- The patient initially diagnosed with presumed tubercular panuveitis progressed to panophthalmitis.
Findings:
- Multidrug-resistant *Mycobacterium tuberculosis* was identified as the causative agent.
- Treatment with standard antitubercular therapy and corticosteroids showed a poor response, highlighting diagnostic delays and drug resistance.
- A literature review of anterior tuberculous scleritis cases was conducted.
Implications:
- This case underscores the diagnostic difficulties in tuberculous scleritis.
- Therapeutic failure should prompt investigation for drug resistance to prevent devastating ocular outcomes.
- Early and accurate diagnosis, including drug susceptibility testing, is vital for effective management.
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