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Updated: Nov 22, 2025

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
08:56

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

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Molecular Characteristics of N1-Methyladenosine Regulators and Their Correlation with Overall Cancer Survival

Juan Li1,2, Chunting Zhang1,2, Xin Yuan1,2

  • 1Gene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.

DNA and Cell Biology
|January 8, 2021
PubMed

Insights

N1-methyladenosine (m1A) regulators impact cancer by altering gene expression and patient survival. This study reveals their epigenetic roles, offering insights for tumor prognosis and targeted therapies.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Oncology

Background:

  • N1-methyladenosine (m1A) is a key RNA modification influencing RNA structure, stability, and protein interactions.
  • Emerging evidence suggests m1A regulators play significant roles in tumorigenesis, but their precise mechanisms and clinical implications are not fully understood.

Purpose of the Study:

  • To systematically investigate the epigenetic characteristics of m1A regulators.
  • To evaluate the clinical relevance and prognostic value of m1A regulators in cancer.

Main Methods:

  • Bioinformatic analysis was employed to assess gene expression patterns.
  • Correlation between m1A regulator expression and carcinogenic pathways was examined.
  • Impact on overall patient survival was analyzed.

Main Results:

  • Significant alterations in m1A regulator gene expression were observed across various cancers.
  • These expression changes were linked to the modulation of key carcinogenic pathways.
  • m1A regulator expression levels were found to be significantly associated with patient survival outcomes.

Conclusions:

  • m1A regulators exhibit widespread epigenetic alterations in tumors.
  • These regulators are implicated in cancer development and progression through pathway modulation.
  • m1A regulators represent potential biomarkers for tumor prognosis and novel targets for cancer therapy.
Keywords:
N1-methyladenosineoverall survivalpan-cancer

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