Interactive gene networks with KNIT
D S Magruder1,2, A M Liebhoff1, J Bethune1
1Institute for Medical Systems Biology, bAIome - Center for Biomedical AI, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Summary:
KNIT is a web application that provides a hierarchical, directed graph on how a set of genes is connected to a particular gene of interest. Its primary aim is to aid researchers in discerning direct from indirect effects that a gene might have on the expression of other genes and molecular pathways, a very common problem in omics analysis. As such, KNIT provides deep contextual information for experiments where gene or protein expression might be changed, such as gene knock-out and overexpression experiments.
Availability And Implementation:
KNIT is publicly available at http://knit.ims.bio. It is implemented with Django and Nuxtjs, with all major browsers supported.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
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