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Longitudinal cognitive and functional changes in primary progressive aphasia.

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Summary
This summary is machine-generated.

Cognitive decline in primary progressive aphasia (PPA) variants is distinct over time, with logopenic PPA (lv-PPA) showing more pervasive cognitive impairment. Routine assessment of cognition and function is vital for accurate diagnosis and support.

Keywords:
Addenbrooke’s Cognitive ExaminationCognitive assessmentDementia stagingFunctional capacityLongitudinal assessment

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Area of Science:

  • Neurology
  • Cognitive Science
  • Linguistics

Background:

  • Primary progressive aphasia (PPA) is typically diagnosed by language deficits.
  • Cognitive and functional changes over time in PPA variants are less understood.
  • Understanding these changes is crucial for patient management.

Purpose of the Study:

  • To longitudinally examine cognitive profiles across PPA variants.
  • To determine how cognition impacts functional capacity over time.
  • To differentiate cognitive trajectories in logopenic (lv-PPA), non-fluent (nfv-PPA), and semantic (sv-PPA) variants.

Main Methods:

  • Longitudinal assessment of 147 PPA patients using the Addenbrooke's Cognitive Examination-III (ACE-III).
  • Analysis of total ACE-III scores and cognitive subdomains.
  • Mixed and hierarchical regression modeling to assess cognition's contribution to function.

Main Results:

  • Logopenic PPA (lv-PPA) exhibited a faster global cognitive decline rate than nfv-PPA and sv-PPA.
  • Attention and visuospatial domains declined more rapidly in lv-PPA.
  • Memory deficits were more severe in lv-PPA throughout the study.
  • Functional decline was similar across variants, but cognitive impact varied.

Conclusions:

  • Distinct cognitive profiles exist at baseline and evolve differently in PPA variants.
  • Cognitive decline in lv-PPA is more widespread and severe.
  • Cognition and functional capacity have a complex, variant-specific interplay.
  • Routine cognitive and functional assessments are essential for PPA diagnosis and care.