Related Experiment Video

Updated: Nov 22, 2025

Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay
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Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay

Published on: September 27, 2024

751

Conformational Dynamics of Deubiquitinase A and Functional Implications

Ashish Kabra1, Ying Li1

  • 1Department of Chemistry, University of Louisville, 2320 South Brook Street, Louisville, Kentucky 40208, United States.

Biochemistry
|January 8, 2021
PubMed
Summary

Deubiquitinase A (DUBA) dynamics were studied using NMR. Phosphorylation at S177 synchronizes motions, with distinct dynamics in helix α1 and α6 contributing to DUBA activation.

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