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Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
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Updated: Nov 22, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
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Self-Assembled Protein- and Peptide-Based Nanomaterials.

Priya Katyal1, Michael Meleties1, Jin K Montclare1,2,3,4

  • 1Department of Chemical and Biomolecular Engineering, Tandon School of Engineering, New York University, Brooklyn, New York 11201, United States.

ACS Biomaterials Science & Engineering
|January 8, 2021
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Researchers are creating new protein and peptide nanomaterials, focusing on self-assembling nanofibers and nanoparticles for drug and gene delivery applications.

Keywords:
drug deliverynanomaterialsprotein engineeringprotein-based fibersprotein-based micellesself-assembly

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Protein Engineering

Background:

  • Proteins and peptides possess unique self-assembly properties.
  • These properties enable the creation of advanced nanoassemblies.
  • These nanoassemblies hold promise for next-generation biomaterials.

Purpose of the Study:

  • To review self-assembled protein- and peptide-based nanomaterials.
  • To highlight nanofibers and nanoparticles as key structures.
  • To discuss their therapeutic and gene delivery applications.

Main Methods:

  • Literature review of self-assembled protein and peptide nanomaterials.
  • Focus on nanofiber and nanoparticle structures.
  • Analysis of applications in drug and gene delivery.

Main Results:

  • Protein and peptide self-assembly yields diverse nanomaterials.
  • Nanofibers and nanoparticles are prominent forms.
  • These nanomaterials show potential in targeted delivery systems.

Conclusions:

  • Self-assembled protein and peptide nanomaterials offer versatile platforms.
  • Nanofibers and nanoparticles are key structures for biomaterial development.
  • Significant potential exists for therapeutic and gene delivery innovations.