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Updated: Nov 22, 2025

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

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Published on: October 23, 2015

Biodegradable Water-Based Polyurethane Shape Memory Elastomers for Bone Tissue Engineering.

Yu-Jen Wang¹, U-Ser Jeng², Shan-Hui Hsu^1,3,4

¹Institute of Polymer Science and Engineering, National Taiwan University, No. 1 Sec. 4 Roosevelt Road, Taipei 10617, Taiwan, R.O.C.

ACS Biomaterials Science & Engineering

|January 9, 2021

Summary

This summary is machine-generated.

Biodegradable shape memory polyurethane scaffolds with superparamagnetic iron oxide nanoparticles promote bone regeneration. These 3D printed bone scaffolds offer improved osteogenic induction and may serve as customized bone substitutes.

Keywords:

3D printed scaffold bone tissue engineering mesenchymal stem cells (MSCs)shape memory polyurethane elastomer superparamagnetic iron oxide

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Shape Memory Polymers for Active Cell Culture

Shape Memory Polymers for Active Cell Culture

Published on: July 4, 2011

Area of Science:

Biomaterials Science
Tissue Engineering
Polymer Chemistry

Background:

Shape memory polymers (SMPs) offer unique properties for biomedical applications.
Biodegradable SMPs are promising for bone scaffolds.
Superparamagnetic iron oxide nanoparticles (SPIO NPs) enhance osteogenic induction in human mesenchymal stem cells (hMSCs).

Purpose of the Study:

To synthesize and characterize water-based biodegradable shape memory polyurethane (PU) ink for 3D printing bone scaffolds.
To incorporate SPIO NPs into PU scaffolds to promote osteogenic induction and improve shape fixity.
To evaluate the printability, shape memory properties, and osteogenic potential of the fabricated scaffolds.

Main Methods:

Synthesized water-based biodegradable shape memory PU ink with SPIO NPs and viscosity enhancers (PEO or gelatin).
Fabricated bone scaffolds using a microextrusion-based low-temperature fuse deposition manufacturing (LFDM) platform.
Assessed scaffold printability, shape memory properties (fixity and recovery) in air and water, and hMSC proliferation and osteogenesis.

Main Results:

Both PU-PEO and PU-gelatin inks exhibited excellent printability.
PU-PEO scaffolds demonstrated superior shape fixity and recovery compared to PU-gelatin scaffolds.
Scaffolds with SPIO NPs significantly enhanced osteogenesis, with PU/PEO/SPIO showing faster SPIO release and greater osteogenic effect (2.7x increase in collagen) than PU/gelatin/SPIO (1.5x increase).
Gelatin-based scaffolds showed better hMSC proliferation, indicating higher biocompatibility than PEO-based scaffolds.

Conclusions:

3D printed biodegradable PU scaffolds incorporating SPIO NPs possess shape memory properties and osteogenic potential.
These scaffolds are suitable for bone tissue engineering and could be utilized as customized bone substitutes in minimally invasive surgery.
The combination of biodegradability, shape memory effect, and osteoinductive properties makes these scaffolds highly promising for orthopedic applications.